• Pediatric blood & cancer · Jul 2010

    Kawasaki disease preceding haemophagocytic lymphohistiocytosis: challenges for developing world practitioners.

    • Marc Hendricks, Shakti Pillay, Alan Davidson, Rik De Decker, and John Lawrenson.
    • Paediatric Haematology Oncology Service, Department of Paediatric Medicine, Red Cross War Memorial Children's Hospital, School of Child and Adolescent Health, University of Cape Town, Rondebosch, Cape Town, South Africa. marc.hendricks@uct.ac.za
    • Pediatr Blood Cancer. 2010 Jul 1; 54 (7): 1023-5.

    AbstractKawasaki disease (KD) is a recognised precipitant of haemophagocytic lymphohistiocytosis (HLH). Although KD has been previously described in the developing world, there are no reported cases of KD preceding HLH. We report a case of a child with a persistent rash and unremitting fever consistent with the diagnosis of KD, who was found to have HLH, after intravenous gamma globulin failed to produce a clinical response. The diagnosis was made using the revised diagnostic criteria for HLH from the Histiocyte Society (1994). She fulfilled six of the eight clinical and laboratory criteria needed to make the diagnosis.Copyright 2010 Wiley-Liss, Inc.

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