• Francesca Mattei, Florence Guida, Mireille Matrat, Sylvie Cenée, Diane Cyr, Marie Sanchez, Loredana Radoi, Gwenn Menvielle, Fatima Jellouli, Matthieu Carton, Simona Bara, Emilie Marrer, Danièle Luce, and Isabelle Stücker.
• INSERM, UMRS 1018, CESP Centre for Research in Epidemiology and Population Health, Environmental Epidemiology of Cancer, Villejuif, France University of Paris Sud 11, UMRS 1018, Villejuif, France.
• Occup Environ Med. 2014 Oct 1;71(10):681-9.

ObjectiveTo investigate the role of occupational exposure to chlorinated solvents in lung cancer aetiology.MethodsICARE (Investigation of occupational and environmental CAuses of REspiratory cancers) is a French, multicentre, population-based, case-control study. Information on the lifelong work history of 2926 cases and 3555 controls was collected using standardised questionnaires. Occupational exposures were assessed using job-exposure matrices for five chlorinated solvents. Solvents were studied separately and in combinations. ORs were computed using unconditional logistic regression models adjusted for classic risk factors, including a history of cigarette smoking and exposure to asbestos. Adjustment for socioeconomic status (SES) was also made.ResultsAfter adjustment for exposure to asbestos, we observed a positive, statistically significant association with lung cancer for men and women exposed to a combination of perchloroethylene (PCE), trichloroethylene and dichloromethane (DCM). Further adjustment for SES slightly decreased this association. In contrast, no statistically significant associations were found for other solvent combinations.ConclusionsThese results suggest that exposure to PCE may constitute a risk factor for lung cancer, especially among women, who seem to have a higher prevalence of exposure than men.Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

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