• N. Engl. J. Med. · Feb 2008

    Hepatitis E virus and chronic hepatitis in organ-transplant recipients.

    • Nassim Kamar, Janick Selves, Jean-Michel Mansuy, Leila Ouezzani, Jean-Marie Péron, Joëlle Guitard, Olivier Cointault, Laure Esposito, Florence Abravanel, Marie Danjoux, Dominique Durand, Jean-Pierre Vinel, Jacques Izopet, and Lionel Rostaing.
    • Department of Nephrology, Dialysis, and Multiorgan Transplantation, Centre Hospitalier Universitaire, Rangueil, France. kamar.n@chu-toulouse.fr
    • N. Engl. J. Med. 2008 Feb 21; 358 (8): 811-7.

    AbstractHepatitis E virus (HEV) is considered an agent responsible for acute hepatitis that does not progress to chronic hepatitis. We identified 14 cases of acute HEV infection in three patients receiving liver transplants, nine receiving kidney transplants, and two receiving kidney and pancreas transplants. All patients were positive for serum HEV RNA. Chronic hepatitis developed in eight patients, as confirmed by persistently elevated aminotransferase levels, serum HEV RNA, and histologic features of chronic hepatitis. The time from transplantation to diagnosis was significantly shorter and the total counts of lymphocytes and of CD2, CD3, and CD4 T cells were significantly lower in patients in whom chronic disease developed.Copyright 2008 Massachusetts Medical Society.

      Pubmed     Free full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…