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- Ross Leader, Jake Cowen, and Surya Panicker Rajeev.
- Faculty of Health and Life Sciences, University of Liverpool, Liverpool, UK.
- BMJ Case Rep. 2019 Sep 19; 12 (9).
AbstractSodium glucose co-transporter-2 inhibitors (SGLT2-i) have become a popular therapeutic strategy in the management of hyperglycaemia in type 2 diabetes mellitus. The primary site of action of SGLT2-i is at the proximal renal convoluted tubule. They work by blocking SGLT2 receptors, sodium-dependent glucose co-transport molecules, which in turn prevents glucose reabsorption, facilitating glucosuria, improving glycaemic control as well as a moderate degree of weight loss. We report the case of a 51-year-old woman admitted to the acute medical unit with abdominal pain and vomiting, who was diagnosed with euglycaemic diabetic ketoacidosis secondary to recent initiation of an SGLT2-i medication (dapagliflozin). Clinicians should be aware of this rare side effect of SGLT2-i, to circumvent delays in patient management.© BMJ Publishing Group Limited 2019. No commercial re-use. See rights and permissions. Published by BMJ.
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