• Eirini Apostolidou, Herbert D Aronow, Charles E Beale, Dhaval Kolte, Kevin F Kennedy, Frank W Sellke, Paul C Gordon, Barry Sharaf, and Afshin Ehsan.
• Division of Cardiology and Cardiothoracic Surgery, Alpert Medical School of Brown University, Providence, Rhode Island. Electronic address: eirini_apostolidou@brown.edu.
• Ann. Thorac. Surg. 2019 Jun 1; 107 (6): 1791-1798.

BackgroundWe evaluated the association between postprocedural packed red blood cell transfusion and morbidity and mortality among patients undergoing transcatheter aortic valve replacement.MethodsWe retrospectively analyzed 429 patients with severe aortic stenosis who underwent transcatheter aortic valve replacement. Propensity-score adjusted multivariable logistic and Cox regression models were used to determine the association of packed red blood cell transfusion with the composite endpoint of death, myocardial infarction, and stroke at 30 days and in hospital, and 1-year mortality.ResultsPatients receiving transfusions had a higher 30-day and in-hospital incidence of death, myocardial infarction, or stroke when compared with patients who did not receive transfusions (hazard ratio 2.03, 95% confidence interval: 1.02 to 4.07, p = 0.045; and hazard ratio 2.46, 95% confidence interval: 1.12 to 5.41, p = 0.025, respectively). Postprocedural transfusion was independently associated with 1-year mortality (hazard ratio 2.65, 95% confidence interval: 1.21 to 5.80, p = 0.015).ConclusionsPacked red blood cell transfusion for patients undergoing transcatheter aortic valve replacement is associated with an increased incidence of adverse outcomes during hospitalization and at 30-day and 1-year follow-up.Copyright © 2019 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.

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