• Antimicrob. Agents Chemother. · Jan 2019

    ARGONAUT-I: Activity of Cefiderocol (S-649266), a Siderophore Cephalosporin, against Gram-Negative Bacteria, Including Carbapenem-Resistant Nonfermenters and Enterobacteriaceae with Defined Extended-Spectrum β-Lactamases and Carbapenemases.

    • Michael R Jacobs, Ayman M Abdelhamed, Caryn E Good, Daniel D Rhoads, Kristine M Hujer, Andrea M Hujer, T Nicholas Domitrovic, Susan D Rudin, Sandra S Richter, David van Duin, Barry N Kreiswirth, Chris Greco, Derrick E Fouts, and Robert A Bonomo.
    • Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USA mrj6@case.edu robert.bonomo@va.gov.
    • Antimicrob. Agents Chemother. 2019 Jan 1; 63 (1).

    AbstractThe activity of the siderophore cephalosporin cefiderocol is targeted against carbapenem-resistant Gram-negative bacteria. In this study, the activity of cefiderocol against characterized carbapenem-resistant Acinetobacter baumannii complex, Stenotrophomonas maltophilia, Pseudomonas aeruginosa, and Enterobacteriaceae strains was determined by microdilution in iron-depleted Mueller-Hinton broth. The MIC90s against A. baumannii, S. maltophilia, and P. aeruginosa were 1, 0.25, and 0.5 mg/liter, respectively. Against Enterobacteriaceae, the MIC90 was 1 mg/liter for the group harboring OXA-48-like, 2 mg/liter for the group harboring KPC-3, and 8 mg/liter for the group harboring TEM/SHV ESBL, NDM, and KPC-2.Copyright © 2018 American Society for Microbiology.

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