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Pediatr. Clin. North Am. · Oct 2017
ReviewAdjunctive Steroid Therapy for Treatment of Pediatric Septic Shock.
- Jerry J Zimmerman.
- Pediatric Critical Care Medicine, Seattle Children's Hospital, Harborview Medical Center, University of Washington School of Medicine, 4800 Sand Point Way Northeast, Room FA.2.300-B, Seattle, WA 98105, USA. Electronic address: jerry.zimmerman@seattlechildrens.org.
- Pediatr. Clin. North Am. 2017 Oct 1; 64 (5): 1133-1146.
AbstractSeptic shock remains the major cause of childhood morbidity and mortality worldwide. Although early sepsis recognition, fluid resuscitation, timely administration of antimicrobials, and vasoactive-inotropic drug infusions are all key to achieving good sepsis outcomes, therapy using various steroid drug classes remains an attractive adjunctive intervention to minimize the duration of septic shock and transition to multiple organ dysfunction syndrome. All steroid drug classes possess biological plausibility to affect a beneficial clinical effect among children with septic shock, but none has undergone rigorous, prospective assessment in a large, high-quality pediatric interventional trial.Copyright © 2017 Elsevier Inc. All rights reserved.
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