• Mohammad Kazem Fallahzadeh, Banafshe Dormanesh, Mohammad Mahdi Sagheb, Jamshid Roozbeh, Ghazal Vessal, Maryam Pakfetrat, Yahya Daneshbod, Eskandar Kamali-Sarvestani, and Kamran B Lankarani.
• AJA University of Medical Sciences, Tehran, Iran. kazem.fa@gmail.com
• Am. J. Kidney Dis. 2012 Dec 1;60(6):896-903.

BackgroundA large proportion of patients with type 2 diabetes mellitus have diabetic nephropathy. Despite current therapies including renin-angiotensin system inhibitors, diabetic nephropathy progresses to end-stage renal disease in most of these patients. Therefore, there is an urgent need to find new treatments for such patients. The aim of this study was to evaluate the efficacy of silymarin, an herbal drug with antioxidant and anti-inflammatory properties, in preventing the progression of diabetic nephropathy.Study DesignRandomized, double-blind, placebo-controlled, 2-arm parallel trial.Setting & Participants60 patients with type 2 diabetes with macroalbuminuria (urinary albumin excretion >300 mg/24 h) despite treatment with the maximum dose of a renin-angiotensin system inhibitor for more than 6 months and estimated glomerular filtration rate >30 mL/min/1.73 m(2).InterventionPatients were randomly assigned to 2 equal groups to receive three 140-mg tablets of silymarin or 3 tablets of placebo daily for 3 months.OutcomesThe primary outcome was absolute change in urinary albumin-creatinine ratio (UACR) from baseline to the end of the treatment phase.MeasurementsUACR and urinary and serum levels of TNF-α (tumor necrosis factor α; an inflammatory marker), malondialdehyde (MDA; an oxidative stress marker), and TGFβ (transforming growth factor β; a marker of fibrosis) at baseline and the end of the treatment phase.ResultsAlthough UACR decreased in both groups, this decrement was significantly higher in the silymarin compared with the placebo group; mean difference in change in UACR between the 2 groups was -347 (95% CI, -690 to -4) mg/g. Urinary levels of TNF-α and urinary and serum levels of MDA also decreased significantly in the silymarin compared with the placebo group.LimitationsSmall sample size and short duration of the treatment phase.ConclusionsSilymarin reduces urinary excretion of albumin, TNF-α, and MDA in patients with diabetic nephropathy and may be considered as a novel addition to the anti-diabetic nephropathy armamentarium.Copyright © 2012 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.

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