• Mohammad Hossein Baradaranfar, Zeynab Sadat Ahmadi, Mohammad Hossein Dadgarnia, Mohammad Hossein Bemanian, Saeid Atighechi, Ghasem Karimi, Abolhasan Halvani, Nasim Behniafard, Amin Baradaranfar, and Tohid Emami Meybodi.
• Department of Otolaryngology, Head and Neck Surgery, Rhinology Research Center, Shahid Sadoughi University of Medical Science and Health Services, Yazd, Iran, rhinology_research@ssu.ac.ir.
• Eur Arch Otorhinolaryngol. 2014 Feb 1; 271 (2): 311-6.

AbstractChronic rhinosinusitis is a common inflammatory condition in western countries. Nasal polyposis has different symptoms such as nasal obstruction, anterior or posterior nasal drip, reduced sense of smell, and facial pain. Medical and endoscopic treatments are the two main treatments for nasal polyposis. Our aim was to compare the efficacy of different methods on olfactory function. This is a non-randomized clinical trial study that was done on 60 patients who were divided into two groups (medical and surgical). Patients were matched based on age, history of smoking, and the severity of obstruction. The radiologist score of Lund-Mackay staging system was used to match patients in two arms of the trial based on the severity of nasal obstruction. Patients in surgery groups underwent functional endoscopic sinus surgery under general anesthesia and then received Fluticasone propionate nasal spray for 8 weeks (400 mcg bd). Patients in the medical group were only prescribed with Fluticasone propionate with the same duration and same dose as mentioned. As a result of treatment protocol, both medical and surgical group experienced improvement in olfactory function but statistical analyses revealed that surgery resulted in better resolution of symptoms. Our observation revealed that combined treatment had a better effect than medical treatment in restoring olfaction in patients with nasal polyposis.

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