• Michael Stacey, Robert M Gifford, and David Woods.
• Defence Medical Services and Chelsea and Westminster NHS Foundation Trust, London, UK, senior lecturer, Royal Centre for Defence Medicine, Birmingham, UK, honorary clinical research fellow, Imperial College London, London, UK and visiting research fellow, Leeds Beckett University, Leeds, UK m.stacey13@imperial.ac.uk.
• Clin Med (Lond). 2021 Sep 1; 21 (5): e541e542e541-e542.

AbstractThe National Patient Safety Alert supporting early recognition and treatment of adrenal crisis is a vital new component of care for adults affected by primary adrenal insufficiency. Benefits for patients with secondary and tertiary adrenal insufficiency need to be weighed alongside other considerations such as security of the diagnosis, relative likelihood of adrenal crisis and potential for anxiety and distress from assigning 'physical dependency' in relation to glucocorticoid therapy. All clinicians must be vigilant for and responsive to managing risks of adrenal crisis in at-risk patients, while avoiding diagnostic anchoring in the context of acute illness. More research is required to help define who is at greatest risk of adverse outcomes (including avoidance of therapeutic glucocorticoid therapy for fear of adrenal insufficiency) and a cross-specialty approach is advocated.© Royal College of Physicians 2021. All rights reserved.

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