• Medicina clinica · Jun 2022

    Observational Study

    Influence of statin treatment in a cohort of patients admitted for COVID-19.

    • Juan R Rey, José Luis Merino Llorens, Ángel Manuel Iniesta Manjavacas, Sandra Ofelia Rosillo Rodríguez, Sergio Castrejón-Castrejón, Emilio Arbas-Redondo, Isabel Dolores Poveda-Pinedo, Daniel Tebar-Márquez, Andrea Severo-Sánchez, Borja Rivero-Santana, Víctor Juárez-Olmos, Marcel Martínez-Cossiani, Antonio Buño-Soto, Luis Gonzalez-Valle, Alicia Herrero-Ambrosio, Esteban López-de-Sá, and Juan Caro-Codón.
    • Servicio de Cardiología, Hospital Universitario La Paz, Madrid, España. Electronic address: juanr.rey@salud.madrid.org.
    • Med Clin (Barc). 2022 Jun 24; 158 (12): 586595586-595.

    Aims And ObjectivesStatins have been proposed as potentially useful agents for modulating the host response in COVID-19. However, solid evidence-based recommendations are still lacking. Our aim was to study the association between statin use and clinical outcomes in a large cohort of hospitalized patients with SARS-CoV-2 infection, as well as the specific consequences of chronic treatment withdrawal during hospital admission.Material And MethodsRetrospective observational study including 2191 hospitalized patients with confirmed SARS-CoV-2 infection.ResultsMean age was 68.0±17.8 years and 597 (27.3%) patients died during follow-up. A total of 827 patients (37.7% of the whole sample), received chronic treatment with statins. Even though they underwent more frequent admissions in critical care units, chronic treatment with statins was not independently associated with all-cause mortality [HR 0.95 (0.72-1.25)]. During the whole hospital admission, 371 patients (16.9%) received at least one dose of statin. Although these patients had a significantly worse clinical profile, both treatment with statins during admission [HR 1.03 (0.78-1.35)] and withdrawal of chronic statin treatment [HR 1.01 (0.78-1.30)] showed a neutral effect in mortality. However, patients treated with statins presented more frequently hepatic cytolysis, rhabdomyolysis and thrombotic/hemorrhagic events.ConclusionsIn this large cohort of hospitalized COVID-19 patients, statins were not independently associated with all-cause mortality during follow-up. Clinically relevant statin-associated adverse effects should be carefully monitored during hospital admission.Copyright © 2021 Elsevier España, S.L.U. All rights reserved.

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