• Critical care clinics · Oct 2021

    Review

    Pathophysiology of Acute Respiratory Distress Syndrome and COVID-19 Lung Injury.

    • Kai Erik Swenson and Erik Richard Swenson.
    • Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, 55 Fruit Street, BUL 148, Boston, MA 02114, USA; Division of Pulmonary, Critical Care, and Sleep Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA. Electronic address: keswenson@mgh.harvard.edu.
    • Crit Care Clin. 2021 Oct 1; 37 (4): 749776749-776.

    AbstractThe pathophysiology of acute respiratory distress syndrome (ARDS) is marked by inflammation-mediated disruptions in alveolar-capillary permeability, edema formation, reduced alveolar clearance and collapse/derecruitment, reduced compliance, increased pulmonary vascular resistance, and resulting gas exchange abnormalities due to shunting and ventilation-perfusion mismatch. Mechanical ventilation, especially in the setting of regional disease heterogeneity, can propagate ventilator-associated injury patterns including barotrauma/volutrauma and atelectrauma. Lung injury due to the novel coronavirus SARS-CoV-2 resembles other causes of ARDS, though its initial clinical characteristics may include more profound hypoxemia and loss of dyspnea perception with less radiologically-evident lung injury, a pattern not described previously in ARDS.Copyright © 2021 Elsevier Inc. All rights reserved.

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