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Critical care clinics · Oct 2021
ReviewGenetics of Acute Respiratory Distress Syndrome: Pathways to Precision.
- Heather M Giannini and Nuala J Meyer.
- University of Pennsylvania Perelman School of Medicine, 3400 Spruce Street, 5038 Gates Building, Philadelphia, PA 19104, USA.
- Crit Care Clin. 2021 Oct 1; 37 (4): 817-834.
AbstractClinical risk factors alone fail to fully explain acute respiratory distress syndrome (ARDS) risk or ARDS death, suggesting that individual risk factors contribute. The goals of genomic ARDS studies include better mechanistic understanding, identifying dysregulated pathways that may be amenable to pharmacologic targeting, using genomic causal inference techniques to find measurable traits with meaning, and deconvoluting ARDS heterogeneity by proving reproducible subpopulations that may share a unique biology. This article discusses the latest advances in ARDS genomics, provides historical perspective, and highlights some of the ways that the coronavirus disease 2019 (COVID-19) pandemic is accelerating genomic ARDS research.Copyright © 2021 Elsevier Inc. All rights reserved.
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