• Murat Oksuz, Suheyla Abitagaoglu, Ahmet Kaciroglu, Ceren Koksal, Burak Yagmur Ozturk, Ozcan Erel, Almila Senat, and Dilek Erdogan Ari.
• Anesthesiology and Reanimation Department, University of Health Sciences Sancaktepe Şehit Prof. Dr. İlhan Varank Health Application and Research Center, Istanbul, Turkey.
• Int. J. Clin. Pract. 2021 Dec 1; 75 (12): e14948.

Background/AimThe aim of this study was to evaluate the effects of general anaesthesia and ultrasonography-guided interscalene block on pain and oxidative stress evaluated by thiol-disulphide balance and C-reactive protein levels in patients undergoing shoulder arthroscopy.Materials And MethodsA total of 42 patients aged 18-75 years who were scheduled to undergo shoulder arthroscopy were randomised into interscalene block group (Group-IB, n = 20) and general anaesthesia group (Group-GA, n = 22). All patients received patient-controlled analgesia during the postoperative period. Additional analgesics were administered to patients with a visual analogue scale score of >4. Native-thiol, total-thiol, disulphide and C-reactive protein levels were measured. Patients' visual analogue scale scores, morphine and additional analgesic consumption were recorded. A shift in thiol-disulphide balance towards decreased thiol and increased disulphide levels was regarded as an indicator of oxidative stress.ResultsPain level, morphine and additional analgesic consumption were higher in Group-GA. Native-thiol and total-thiol levels were higher in Group-IB postoperatively and also disulphide levels were lower at postoperative 18 hours. C-reactive protein levels were similar in both the groups.ConclusionInterscalene block induced less oxidative stress during the postoperative period, as evaluated by thiol-disulphide balance. In shoulder arthroscopy, interscalene block provides more stable haemodynamics perioperatively and facilitates better postoperative pain control.© 2021 John Wiley & Sons Ltd.

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