• Clinics in chest medicine · Sep 2016

    Review

    α1-Antitrypsin Deficiency.

    • Umur Hatipoğlu and James K Stoller.
    • Respiratory Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Desk A-90, Cleveland, OH 44195, USA. Electronic address: hatipou@ccf.org.
    • Clin. Chest Med. 2016 Sep 1; 37 (3): 487-504.

    Abstractα1-Antitrypsin deficiency is an autosomal codominant condition that predisposes to emphysema and cirrhosis. The condition is common but grossly under-recognized. Identifying patients' α1-antitrypsin deficiency has important management implications (ie, smoking cessation, genetic and occupational counseling, and specific treatment with the infusion of pooled human plasma α1-antitrypsin). The weight of evidence suggests that augmentation therapy slows the progression of emphysema in individuals with severe α1-antitrypsin deficiency.Copyright © 2016 Elsevier Inc. All rights reserved.

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