• Mohammad Zare, Rasul Norouzi, Vahid Shayegannejad, Fereshteh Ashtari, Majid Ghasemi, Hemaseh Tavahen, and Ali Masaeli.
• Department of Neurology, Isfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
• J Res Med Sci. 2013 Jul 1; 18 (7): 558-60.

BackgroundThere is a broad variation in reported frequencies of seizure in multiple sclerosis (MS). In this study, the seizure and its characteristics analyzed among a large group of patients with MS.Patients And MethodsWe reviewed the medical records of all definite MS patients referred to the MS Clinic of Kashani hospital, Isfahan, Iran, between 2007 and 2011.ResultsAltogether, 34 cases with seizure activity identified among the 920 definite MS subjects (3.69%). Five excluded due to the other probable etiologies rather than MS. In the remained 29 patients (3.15%), the type of seizure was mostly generalized (79.3%); interictal electroencephalography showed an abnormal pattern in 84.6%, brain magnetic resonance imaging revealed subcortical white mater lesions in 84.6% of patients. The mean duration of MS onsets was 8.17 years and the mean interval between MS onset and the first seizure occurrence was 3.7 years. In general, response to antiepileptic treatment was excellent.ConclusionSeizures can occur at any stage during the course of MS, but it is more common during the early stages.

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