• Masoud Etemadifar, Alimohammad Fatemi, Hourossadat Hashemijazi, and Amir Kazemizadeh.
• Medical School, Isfahan University of Medical Sciences, Isfahan, Iran ; Isfahan Neuroscience Research Center, Isfahan University of Medical Sciences, Isfahan, Iran ; Isfahan Eye Research Center, Feiz Hospital, Isfahan University of Medical Sciences, Isfahan, Iran ; Department of Neurology, Medical School, Isfahan University of Medical Sciences, Isfahan, Iran.
• J Res Med Sci. 2013 Jul 1; 18 (7): 617-20.

BackgroundIt may be difficult to differentiate between the first demyelinating attack and the neurological manifestations of connective tissue diseases.Materials And MethodsA total of 79 patients with optic neuritis were compared with 79 healthy controls. Their blood samples were tested for erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), antiβ2-Glycoprotein I antibody (IgG, IgM), anticardiolipin antibody (IgM, IgG), lupus anticoagulant, anti-double strand DNA (anri-ds DNA), antinuclear antibody (ANA), anti-myeloperoxidae (p-ANCA), and anti-Proteinase 3 (C-ANCA).ResultsIn clinically isolated syndrome group β2-Glycoprotein (IgM) and lupus anti-coagulant were positive in 1.3% of patients whereas ANA was positive in 1.3% and anti-β2-Glycoprotein I (IgM) was positive in 2.5% of control group. No rheumatologic disease was found in objects with positive tests.ConclusionThis study shows no specific difference between two groups.

2 keywords...

hide…