• Indian J Med Res · Jul 2014

    Interleukin-6 (IL-6)-597 A/G (rs1800797) & -174 G/C (rs1800795) gene polymorphisms in type 2 diabetes.

    • Madhukar Saxena, C G Agrawal, Neena Srivastava, and Monisha Banerjee.
    • Department of Zoology, University of Lucknow, Lucknow, India.
    • Indian J Med Res. 2014 Jul 1; 140 (1): 60-8.

    Background & ObjectivesDiabetes is a metabolic pro-inflammatory disorder characterized by chronic hyperglycaemia and increased levels of circulating cytokines suggesting a causal role for inflammation in its aetiology. In order to decipher the role of interleukin-6 (IL-6) in type 2 diabetes mellitus (T2DM) we analyzed two promoter polymorphisms -597 A/G (rs1800797) and -174 G/C (rs1800795) in T2DM cases from north India, and in healthy controls.MethodsDNA was isolated from venous blood samples of T2DM patients (n=213) and normal healthy controls (n=145). Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was performed after biochemical analysis. The genotypic and allelic frequency distributions were analyzed.ResultsThe clinical/biochemical parameters of T2DM cases when compared to controls showed a significant difference. No significant association was observed with -597A/G polymorphism while, -174 G/C showed a highly significant association (P<0.001). In haplotypic analysis, combination of -597GFNx01/-174CFNx01 showed significant association (P=0.010).Interpretation & ConclusionsOur data suggest that IL-6 gene polymorphisms play a prominent role in T2DM disease susceptibility in population from north India.

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