• C Heiss, L M Hoesel, M Pausch, S A Meissner, U Horas, O Kilian, U Wehr, W A Rambeck, and R Schnettler.
• Klinik und Poliklinik für Unfallchirurgie, Universitätsklinikum Giessen-Marburg GmbH, Rudolf-Buchheim-Str. 7, 35385 Giessen, Deutschland. christian.heiss@chiru.med.uni-giessen.de
• Unfallchirurg. 2008 Sep 1; 111 (9): 695-702.

BackgroundThis study investigated the progression and clinical relevance of biochemical resorption marker values during fracture healing in osteoporosis.Patients And MethodsIn 44 patients with distal radius fractures and 29 patients without fractures, the blood and urine concentrations of pyridinoline (PYD), deoxypyridinoline (DPD), N-telopeptides (NTx), and bone sialoprotein (BSP) were recorded on the day of trauma as well as during further progression. All postmenopausal patients underwent bone density measurement. Accordingly, patients were divided into premenopausal, postmenopausal osteoporotic, and postmenopausal nonosteoporotic groups.ResultsBetween the groups, PYD, DPD, and NTx showed significant differences in their initial values. However, their further relative progression was primarily affected by the chosen therapy.ConclusionBone resorption markers can diagnostically point to osteoporosis and are significant parameters in fracture healing.

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