• Yudong Li, Wenchang Li, Yisheng Lu, and Jing Zhang.
• Department of General Medicine, Wuliqiao Community Health Center, Huangpu District, Shanghai, China.
• Medicine (Baltimore). 2021 Sep 17; 100 (37): e27149.

BackgroundRecent studies have suggested a renal protective effect of coffee consumption against development of chronic kidney disease (CKD), although the results remain inconclusive. We performed a protocol for systematic review and meta-analysis to comprehensively investigate this association by summarizing all available data.MethodsAn all-round retrieval will be performed in 5 electronic journal databases from their inception to June 2021, which comprise Medline, PubMed, Embase, ScienceDirect, and the Cochrane Library. The following key words were used on combination with Boolean operators AND or OR: "coffee," "caffeine," "renal insufficiency," "chronic kidney diseases," "chronic renal diseases." Two authors completed the quality assessment using the Newcastle-Ottawa Scale for observational studies. The meta-analysis was conducted using Review Manager 5.3 software from the Cochrane Collaboration (London, UK).ResultsThe findings of this study will be submitted to peer-reviewed journals for publication.ConclusionCoffee consumption may be associated with a lower risk of incident CKD.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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