• Medicine · Sep 2021

    Distribution of normal and pathological OGTTs among pregnant population and non-pregnant women with PCOS - the cross-sectional study.

    • Miroslava Gojnic-Dugalic, Katarina Stefanovic, Aleksandar Stefanovic, Aleksandra Jotic, Nebojsa Lalic, Svetlana Petronijevic-Vrzic, Milos Petronijevic, Tanja Milicic, Ljiljana Lukic, Jovana Todorovic, Stefan Dugalic, Igor Pantic, Dejan Nesic, Milica Stoiljkovic, Dejana Stanisavljevic, and Milan Perovic.
    • Clinical Centre of Serbia, Clinic for Gynaecology and Obstetrics, Serbia.
    • Medicine (Baltimore). 2021 Sep 17; 100 (37): e27232.

    AbstractBoth pregnancy, as physiological, and polycystic ovary syndrome (PCOS), as a pathological condition, carry the risk for developing glucose metabolism abnormalities. In this retrospective cross-sectional study, we hypothesized that pregnancy as a physiological condition carries a higher likelihood for abnormal oral glucose tolerance test (OGTT) results than PCOS as a pathological condition.We have compared the prevalence and likelihood ratios for abnormal OGTT results between non-pregnant women with PCOS (Group A) and pregnant women at 24 to 28 weeks of gestation (Group B). Participants of both study groups underwent glucose tolerance testing with 75 g glucose OGTT. During the study period, 7411 women were tested, 3932 women encompassed Group A, and 3479 women comprised Group B.The numbers of yearly tested pregnant women and the corresponding proportion of tested women among all study participants have decreased during the study period, from 766 to 131 and 89.1% to 20.5%, respectively. Group A had a significantly lower prevalence (4.4%) of pathological OGTT results compared to Group B (8.1%). This has resulted in a 45.427 likelihood ratio (P < .001) for abnormal OGTT results in pregnant women compared to non-pregnant women with PCOS.We might conclude that pregnancy could have a more challenging influence on glucose metabolism and that carries higher risks for abnormal glucose metabolism than PCOS. The awareness of obstetricians regarding physiological changes during pregnancy that predisposes abnormal glucose metabolism is decreasing over time and the compliance concerning OGTT testing of pregnant women is decreasing too.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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