• Dilek Sahin, Atakan Tanacan, Seyit A Erol, Ali T Anuk, Fatma D Y Yetiskin, Huseyin L Keskin, Namik Ozcan, A Seval Ozgu-Erdinc, Elif G Y Eyi, Aykan Yucel, Cuneyt Tayman, Serpil Unlu, Bedia Dinc, Eyup Sari, Aziz A Surel, and Ozlem T Moraloglu.
• Department of Obstetrics and Gynecology, Turkish Ministry of Health, Ankara City Hospital, University of Health Sciences, Ankara, Turkey.
• Int J Gynaecol Obstet. 2021 Mar 1; 152 (3): 328-334.

ObjectiveTo investigate the clinical course and impact of coronavirus disease 2019 (COVID-19) infection on pregnant women.MethodsA prospective cohort study was conducted on pregnant women with confirmed COVID-19 infection. Demographic features, clinical characteristics, and perinatal outcomes were prospectively evaluated.ResultsOf the 533 cases, 161 (30.2%) had co-morbidities and 165 (30.9%) were asymptomatic. Cough (n = 178, 33.4%) and myalgia (n = 168, 31.5%) were the leading symptoms. In total, 261 patients (48.9%) received COVID-19 therapy, 509 (95.5%) had mild disease, 7 (1.3%) were admitted to the intensive care unit (ICU), and invasive mechanical ventilation was necessary in 2 (0.4%) patients. Maternal mortality was observed in 2 (0.4%) cases. Of the patients, 297 (55.7%) were hospitalized, 39 (7.3%) had suspicious radiologic imaging findings, 66 (12.4) had pregnancy complications (preterm delivery [n =22, 4.1%] and miscarriage [n =12, 2.2%] were the most common pregnancy complications), 131 births occurred, and the cesarean section rate was 66.4%. All neonates were negative for COVID-19. The rate of admission to the neonatal ICU was 9.9%. One specimen of breast milk was positive for the infection.ConclusionThe course of COVID-19 was mild in the majority of cases. However, increased rates of pregnancy complications and cesarean delivery were observed.© 2020 International Federation of Gynecology and Obstetrics.

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