• J. Korean Med. Sci. · Jan 2014

    Multicenter Study

    Correction of anemia with continuous erythropoietin receptor activator in Korean patients on long-term hemodialysis.

    • Jieun Oh, Kwon-Wook Joo, Ho-Jun Chin, Dong-Wan Chae, Sung-Gyun Kim, Soo Jin Kim, Wookyung Chung, Sejoong Kim, Wooseong Huh, Ha Young Oh, Bum Soon Choi, Chul-Woo Yang, and Suhnggwon Kim.
    • Department of Internal Medicine, Hallym University College of Medicine, Hallym Kidney Research Institute, Seoul, Korea.
    • J. Korean Med. Sci. 2014 Jan 1; 29 (1): 76-83.

    AbstractContinuous erythropoietin receptor activator (CERA) is an erythropoietin with a long-half life. This study investigated the efficacy of CERA for correcting anemia in Korean patients on dialysis. Patients (≥ 18 yr) who were not receiving any ESAs for more than 8 weeks were randomly assigned to either intravenous CERA once every 2 weeks (n=39) or epoetin beta thrice-weekly (n=41) during a 24-week correction phase. Hemoglobin (Hb) response was defined as increase of Hb by at least 1 g/dL and Hb ≥ 11 g/dL without red blood cell (RBC) transfusion. Median dialysis duration was 1.7 (0.3-20.8) and 1.6 (0.4-13.8) yr in CERA and epoetin beta group, respectively. Hemoglobin response rate of CERA was 79.5% (95% confidence interval [CI], 63.5-90.7). As the lower limit of 95% CI was higher than pre-specified 60% response rate, it can be concluded that CERA corrected anemia (P<0.05). Hb response rate of epoetin beta was 87.8% (95% CI, 73.8-95.9) (P=0.37). Median time to response was 12 weeks in CERA and 10.3 weeks in epoetin beta (P=0.03). It is suggested that once every 2 weeks administration of CERA is effective for correcting anemia in Korean patients on long-term hemodialysis with longer time-to-response than thrice weekly epoetin beta. (ClinicalTrials.gov registry No. NCT00546481).

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