• Pak J Med Sci · Jul 2014

    Association of depression with inflammation in hospitalized patients of myocardial infarction.

    • Yu-Xiu Shang, Wen-Qing Ding, Hong-Yan Qiu, Feng-Ping Zhu, Shu-Zhen Yan, and Xue-Liang Wang.
    • Yu-Xiu Shang, Department of Epidemiology and Biostatistics, School of Medicine, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
    • Pak J Med Sci. 2014 Jul 1; 30 (4): 692697692-7.

    ObjectiveThe aim of this study was to examine the associations between depression and inflammatory markers in patients admitted to the hospital for myocardial infarction.MethodsInflammatory cytokines, including high-sensitivity C-reactive protein (hs-CRP), interleukin (IL)-1β, IL-6, and tumor necrosis factor-α (TNF-α) were assessed in a group of 75 depressed participants (score of ≥ 12) and compared to a control group of 75 nondepressed participants (score < 12), all who had been admitted to the hospital for myocardial infarction. The presence of depressive symptoms was assessed using the Beck Depressive Symptoms Inventory II Scale (BDI-II).ResultsDepressed myocardial infarction participants had significantly greater levels of TNF-α (t = 2.070, P < 0.05) compared with control myocardial infarction participants. The BDI-II score was positively correlated with TNF-α levels (r = 0.222, P < 0.05).ConclusionsThese results indicate that the presence of depressive symptoms is positively associated with TNF-α levels among patients who have suffered from myocardial infarction.

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