• Pak J Med Sci · Jul 2014

    Potential reproductive health effects and oxidative stress associated with exposure to potassium dichromate (K2Cr2O7) and magnesium sulphate (MgSO4) in male mice.

    • Mahmood Rasool, Kalsoom Zaigham, Arif Malik, Muhammad Imran Naseer, Umm-E-HabibaUmm-e-Habiba, Institute of Molecular Biology and Biotechnology, The University of Lahore, Lahore, Pakistan., Abdul Manan, Mahmood Husain Qazi, and Muhammad Asif.
    • Mahmood Rasool, Center of Excellence in Genomic Medicine Research (CEGMR), King Abdulaziz University, Jeddah, Saudi Arabia.
    • Pak J Med Sci. 2014 Jul 1; 30 (4): 819-23.

    ObjectiveTo investigate the potential harmful effects of potassium dichromate and magnesium sulphate causing oxidative stress and reproductive toxicity in adult male mice model.MethodsThe experimental work was conducted on sixty male mice (Mus musculus) divided into three groups. Mice in group B and C received potassium dichromate and magnesium sulphate of 5.0 and 500 mg/Kg body weight/ml respectively, for sixty days. The blood sample was analyzed to assess oxidative stress and cellular damage.ResultsRESULTS showed high malondialdehyde (MDA) and low levels of antioxidant enzymes [catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx)] in both potassium dichromate and magnesium sulphate administrated groups as compared to control group. Reduced number of sperm count and excessive destruction of testicular follicles, including destruction of spermatids, leydig cells and sertoli cells, were also seen in both groups.ConclusionWe concluded from present study that potassium dichromate and magnesium sulphate causes oxidative stress by generation of reactive oxygen species (ROS) and causing DNA damage in testicular cells leading to adverse reproductive abnormalities.

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