• Pak J Med Sci · Sep 2014

    Relationship between TLR4 and NF-κB p65 protein expressions and clinical radiosensitivity of patients with esophageal squamous cell carcinoma.

    • Hua Tang, Feng Wang, Xi-Fa Zhou, Jian Zhou, Ling Chen, Ju-Dong Luo, and En-Ci Xu.
    • Hua Tang, Department of Radiotherapy Oncology, Changzhou Fourth People's Hospital, 68 Honghe Road, Changzhou 213032, Jiangsu Province, P. R. China.
    • Pak J Med Sci. 2014 Sep 1; 30 (5): 982-5.

    ObjectiveTo study the relationship between TLR4 and NF-κB p65 protein expressions in tumor tissues after radiotherapy and clinical radiosensitivity of patients with esophageal squamous cell carcinoma.MethodsA total of 93 patients with esophageal squamous cell carcinoma first treated in our hospital by radiotherapy and surgeries from November 2010 to December 2013 were selected. They were then divided into a severe reaction group, a moderate reaction group and a mild reaction group according to the postoperative pathological examination results of tumor tissues. The expressions of TLR4 and NF-κB p65 in the tumor samples were detected by Western blotting.ResultsCompared with the severe reaction group, the expression levels of TLR4 and NF-κB p65 in the moderate reaction group significantly increased (P<0.05). Similarly, the expression levels of the mild reaction group were significantly higher than those of the moderate reaction group (P<0.05).ConclusionReducing the expression levels of TLR4 and NF-κB p65 proteins may increase the radiosensitivity of patients with esophageal cancer.

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