• Eun Kyoung Ahn, Hye Jin Kam, Dong Kyun Park, Eun Young Jung, Youngho Lee, and Rae Woong Park.
• Department of Biomedical Informatics, Ajou University School of Medicine, Suwon, Korea.
• Pharmacoepidemiol Drug Saf. 2014 Apr 1; 23 (4): 390-7.

ObjectiveTo determine differences in the incidence and risk factors of alerts for drug-drug interaction (DDI) and the rate of alert overrides by an admitting department.MethodsA retrospective cohort study was performed using electronic health records of a Korean tertiary teaching hospital including all hospitalized adult patients for 18 months. The main outcome measures included incidence rates of alerts for DDI and their override, hazard ratios (HRs) for DDI alerts, and odds ratios (ORs) for alert overrides by admitting department (emergency department [ED], general ward [GW], and intensive care unit [ICU]) after adjusting for other known risk factors.ResultsAmong 102 379 incident admissions, 6060 had alerts for DDI (5.4/person-year). After adjusting for covariates, patients admitted to the ED (HR, 4.02; confidence interval [CI], 3.69-4.38) or ICU (HR, 1.62; CI, 1.29-2.04) showed higher risks for DDI compared with those admitted to the GW. The alert-override rate was significantly higher in the ED (OR 1.68) than in the GW; however, there was no significant difference between GW and ICU. The prevalence of DDI alerts and their override rate were also demonstrated.DiscussionThe incidence of DDI and the alert-override rate differed by admitting department. The ED and ICU were associated with higher risks for alerts on DDI than did the GW after adjusting for other known risk factors.ConclusionsAdmitting department was an independent risk factor for alerts and alert overrides. Strategies to reduce alerts and alert overrides should consider the admitting department.Copyright © 2014 John Wiley & Sons, Ltd.

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