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Antimicrob. Agents Chemother. · Sep 1996
Randomized Controlled Trial Multicenter Study Clinical TrialGamma radiation-sterilized, triple-lumen catheters coated with a low concentration of chlorhexidine were not efficacious at preventing catheter infections in intensive care unit patients.
- R J Sherertz, S O Heard, I I Raad, L Gentry, D Bowton, P Scuderi, J Hu, W Carruth, B Satishchandra, J Pepe, A Mosenthal, T Burke, and J Dupuis.
- Section on Infectious Diseases, Bowman Gray School of Medicine, Winston-Salem, North Carolina, USA.
- Antimicrob. Agents Chemother. 1996 Sep 1; 40 (9): 1995-7.
AbstractIn a randomized, double-blind trial, gamma radiation-sterilized, chlorhexidine-coated triple-lumen catheters were compared with uncoated control catheters for their ability to prevent catheter infection in 254 intensive care unit patients. The chlorhexidine coating was not efficacious, and a rabbit model demonstrated that reduction of chlorhexidine activity by gamma radiation sterilization was the likely explanation for the failure.
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