• Monica Cruz-Lemini, Elena Ferriols Perez, Maria Luisa de la Cruz Conty, Africa Caño Aguilar, Maria Begoña Encinas Pardilla, Pilar Prats Rodríguez, Marta Muner Hernando, Laura Forcen Acebal, Pilar Pintado Recarte, Maria Del Carmen Medina Mallen, Noelia Perez Perez, Judit Canet Rodriguez, Ana Villalba Yarza, Olga Nieto Velasco, Pablo Guillermo Del Barrio Fernandez, Carmen Maria Orizales Lago, Beatriz Marcos Puig, Begoña Muñoz Abellana, Laura Fuentes Ricoy, Agueda Rodriguez Vicente, Maria Jesus Janeiro Freire, Macarena Alferez Alvarez-Mallo, Cristina Casanova Pedraz, Onofre Alomar Mateu, Cristina Lesmes Heredia, Juan Carlos Wizner de Alva, Alma Posadas San Juan, Montserrat Macia Badia, Cristina Alvarez Colomo, Antonio Sanchez Muñoz, Laia Pratcorona Alicart, Ruben Alonso Saiz, Monica Lopez Rodriguez, Maria Carmen Barbancho Lopez, Marta Ruth Meca Casbas, Oscar Vaquerizo Ruiz, Eva Moran Antolin, Maria Jose Nuñez Valera, Camino Fernandez Fernandez, Albert Tubau Navarra, Alejandra Maria Cano Garcia, Susana Soldevilla Perez, Irene Gattaca Abasolo, Jose Adanez Garcia, Alberto Puertas Prieto, Rosa Ostos Serna, Guadix MartinMaria Del PilarMDPDepartment of Gynecology and Obstetrics, Virgen Macarena University Hospital, 41009 Sevilla, Spain., Monica Catalina Coello, Silvia Espuelas Malon, Jose Antonio Sainz Bueno, Maria Reyes Granell Escobar, Sara Cruz Melguizo, Oscar Martinez Perez, and On Behalf Of The Spanish Obstetric Emergency Group.
• Department of Gynecology and Obstetrics, Women and Perinatal Health Research Group, Biomedical Research Institute (IIB-Sant Pau), Santa Creu i Sant Pau University Hospital, 08025 Barcelona, Spain.
• Viruses Basel. 2021 Jan 15; 13 (1).

AbstractAround two percent of asymptomatic women in labor test positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Spain. Families and care providers face childbirth with uncertainty. We determined if SARS-CoV-2 infection at delivery among asymptomatic mothers had different obstetric outcomes compared to negative patients. This was a multicenter prospective study based on universal antenatal screening for SARS-CoV-2 infection. A total of 42 hospitals tested women admitted for delivery using polymerase chain reaction, from March to May 2020. We included positive mothers and a sample of negative mothers asymptomatic throughout the antenatal period, with 6-week postpartum follow-up. Association between SARS-CoV-2 and obstetric outcomes was evaluated by multivariate logistic regression analyses. In total, 174 asymptomatic SARS-CoV-2 positive pregnancies were compared with 430 asymptomatic negative pregnancies. No differences were observed between both groups in key maternal and neonatal outcomes at delivery and follow-up, with the exception of prelabor rupture of membranes at term (adjusted odds ratio 1.88, 95% confidence interval 1.13-3.11; p = 0.015). Asymptomatic SARS-CoV-2 positive mothers have higher odds of prelabor rupture of membranes at term, without an increase in perinatal complications, compared to negative mothers. Pregnant women testing positive for SARS-CoV-2 at admission for delivery should be reassured by their healthcare workers in the absence of symptoms.

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