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J. Neurol. Neurosurg. Psychiatr. · Apr 1981
The effect of dantrolene sodium in relation to blood levels in spastic patients after prolonged administration.
- W J Meyler, H Bakker, J J Kok, S Agoston, and H Wesseling.
- J. Neurol. Neurosurg. Psychiatr. 1981 Apr 1; 44 (4): 334-9.
AbstractIn 25 patients with spasticity, pharmacokinetics and effects of dantrolene sodium were investigated after prolonged administration. A beneficial effect occurred in seven patients. The results were better on 100 mg daily than on a higher daily dose. An increase of the daily dose from 200 to 400 mg was not associated with higher blood levels. Many side effects were noted such as: anorexia, nausea, drowsiness, depression and muscle weakness. From this study we conclude that dantrolene sodium is a muscle relaxant with a weak to moderate effect in patients with spasticity; the effect at doses higher than 200 mg daily is probably poor.
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