[Insulin therapy on intensive care should not be too intensive].

Ned Tijdschr Geneeskd · Jan 2009

[Insulin therapy on intensive care should not be too intensive].

Intensive insulin therapy for critically ill patients is implemented as standard therapy in many ICUs, even though the evidence supporting this approach comes from just two studies at a single centre. Moreover, the results could not be repeated in other multicenter trials and there is increasing evidence of a risk of hypoglycaemia. However, it appears that many intensive care specialists have been too zealous in their attempts to attain euglycemia during critical care. A recent RCT with over 6000 patients demonstrated that intensive glucose control increases mortality by 2.4%.

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- Armand R J Girbes and Albertus Beishuizen.
- VU Medisch Centrum, afd. Intensive Care Volwassenen, Amsterdam, The Netherlands. arj.girbes@vumc.nl
- Ned Tijdschr Geneeskd. 2009 Jan 1;153:A609.
AbstractIntensive insulin therapy for critically ill patients is implemented as standard therapy in many ICUs, even though the evidence supporting this approach comes from just two studies at a single centre. Moreover, the results could not be repeated in other multicenter trials and there is increasing evidence of a risk of hypoglycaemia. However, it appears that many intensive care specialists have been too zealous in their attempts to attain euglycemia during critical care. A recent RCT with over 6000 patients demonstrated that intensive glucose control increases mortality by 2.4%.

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[Insulin therapy on intensive care should not be too intensive].

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