• Chia-Chieh Lee, Po-Kai Yang, Li-Ching Chen, Mei-Leng Cheong, Ya-Lun Tsai, and Ming-Song Tsai.
• Department of Obstetrics and Gynecology, Cathay General Hospital, Taipei, Taiwan.
• J Formos Med Assoc. 2022 Jul 1; 121 (7): 1231-1237.

Background/PurposeTo assess the relationship between gene expressions of the magnesium transporters and glucose parameters in pregnant women.MethodsA cohort of women without ongoing or prior medical illnesses was recruited at the start of an early singleton pregnancy. Expression levels of the magnesium transporters-SLC41A1, CNNM2, MAGT1, TRPM6, and TRPM7-were assessed in the peripheral leukocytes, while total calcium and magnesium were assessed in the serum between 10 and 13 weeks gestation. Glucose parameters were assessed between 24 and 28 weeks gestation using the 75 g oral glucose tolerance test.ResultsA total of 208 patients were included in the study. The expressions of the magnesium transports were generally unrelated to age, body mass index (BMI), or serum levels of calcium and magnesium. The magnesium transporters were correlated with each other at baseline (correlation coefficients: 0.31 to 0.51). BMI was a strong predictor of fasting glucose levels, while both BMI and age were strong predictors of post-load glucose levels. The expression of TRPM7 was found to be predictive of 1-h post-load blood glucose after accounting for the effects of age and BMI (β = -0.196, p = 0.020).ConclusionThe increased maternal expression of the magnesium transporter TRPM7 may be associated with decreased glucose tolerance in pregnant women. In particular, the association between TRPM7 and 1-h post-load glucose levels was found to be independent of the effects of age and BMI. Future studies are needed to determine whether a mechanistic relationship can be demonstrated between TRPM7 and glucose metabolism.Copyright © 2021 Formosan Medical Association. Published by Elsevier B.V. All rights reserved.

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