• Man Yin, Linqing Yang, and Yunfei Wang.
• Department of Clinical Medicine, Jining Medical University, Jining, Shandong, China.
• Medicine (Baltimore). 2021 Dec 23; 100 (51): e28239e28239.

RationaleGastric-type endocervical adenocarcinoma (GAS) is a rare type of cervical adenocarcinoma that is a mucinous adenocarcinoma with a variety of gastral patterns. To date, there are no systematic clinical diagnosis and treatment guidelines.Patient ConcernsIn our case, a 49-year-old woman underwent pelvic magnetic resonance imaging (MRI) due to a pelvic mass, and cervical lesions were unexpectedly found. After receiving relevant surgical treatment, the pathological results showed the particularity of the tumor type-cervical gastric adenocarcinoma with a borderline serous tumor of both appendages and the right ovary.DiagnosesPostoperative routine pathological examination showed mucoepithelial metaplasia accompanied by a borderline serous tumor.InterventionsAfter gynecological/urinary ultrasound, blood tests, MRI, cervical biopsy, and uterine curettage, "robot-assisted laparoscopic radical hysterectomy + bilateral salpingectomy-ovariectomy + pelvic lymph node dissection + pelvic adhesiolysis" were performed. After the surgery, the patient was treated with radiotherapy and concurrent chemotherapy.OutcomesAfter the operation, radiotherapy, and chemotherapy, the patient had no tumor recurrence and is still in good condition.LessonsThe diagnosis of GAS is relatively difficult, its clinical manifestations lack specificity, and the pathogenesis has nothing to do with human papillomavirus infection. The patient was misdiagnosed with vaginitis at a local hospital. However, we found that MRI and pathological examination were helpful for the diagnosis of the disease. Although there are no relevant guidelines to explain the treatment principles of GAS, we believe that early surgery is conducive to the prognosis of the disease because GAS has a certain tolerance to radiotherapy and chemotherapy.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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