• Hong-Li Zhao, Hong-Hua Cui, Li-Fang Jin, Meng Zhao, and Wei-Zhang Shen.
• Department of Hematology, The Second Hospital of Jilin University, Changchun, China.
• Medicine (Baltimore). 2021 Dec 23; 100 (51): e28262e28262.

IntroductionThis case report is presented to improve our understanding of the atypical immunophenotype of hairy cell leukemia.Patient ConcernsA 58-year-old woman presented to our department with fatigue for >10 days.DiagnosisThe patient was diagnosed with an increased proportion of abnormal lymphocytes in peripheral blood and bone marrow smear, positive for CD11c, CD19, CD20, CD22, CD25, CD123, CD200, and Kappa, partial expression of CD23, but no expression of CD103, positive for BRAF V600E mutation.Interventions And OutcomesCladribine combined with rituximab achieved complete remission of minor residual disease negativity.ConclusionHairy cell leukemia is rare, and the diagnosis and differential diagnosis should be made by combining the patient's medical history, clinical manifestations, immunophenotype, gene detection, and other means. Purine nucleoside analogs are the first-line treatments.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

32 keywords...

hide…