• Gyu Man Oh, Seun Ja Park, Jae Hyun Kim, Kyoungwon Jung, Sung Eun Kim, Won Moon, Moo In Park, and Hee-Kyung Chang.
• Department of Internal Medicine, Kosin University College of Medicine, Busan, Korea.
• Medicine (Baltimore). 2021 Dec 23; 100 (51): e28422.

RationaleAmyloidosis is a general term that refers to the extracellular deposition of amyloid. The amyloid can also be deposited in a single organ. However, cases of localized gastric amyloidosis have rarely been reported. Here, we report a case of localized gastric amyloidosis that was successfully treated with endoscopic submucosal dissection.Patient ConcernA 60-years-old man underwent esophagogastroduodenoscopy as part of a regular check-up without any comorbidities or symptoms.DiagnosticsA 12 mm-sized, round, elevated lesion with a central depression, which was covered with normal mucosa, and located on the greater curvature of the lower body of the stomach was discovered during endoscopy. Subsequently, endoscopic ultrasonography was performed, which revealed a 11.7 mm-sized, hypoechoic, heterogeneous lesion located in the muscularis mucosa and submucosa. A biopsy was performed, and amyloid deposition was confirmed. Although other investigations for checking systemic amyloidosis were performed, there were no specific findings. Therefore, the final diagnosis was localized gastric amyloidosis.InterventionsEndoscopic submucosal dissection was performed according to the patient's request and the lesion was completely removed.OutcomesThe patient was followed-up for 3 years without any recurrence.ConclusionsEndoscopic submucosal dissection can be good diagnostic and treatment option for localized gastric amyloidosis.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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