• Lorenzo A D'Angelo, Yingyot Arora, and Roger G Carrillo.
• Palmetto General Hospital, Cardiothoracic Surgery, Hialeah, FL. Electronic address: Ldangelop@gmail.com.
• Chest. 2022 Jan 1; 161 (1): e1-e4.

AbstractWe report the first case of a patient with myxofibrosarcoma (MFS) who presented acutely with a rib fracture and developed a rapidly expanding loculated hemothorax after chest trauma. The patient was taken to the operating room for evacuation of hemothorax, and samples and biopsy specimens were taken for cytologic and pathologic examination. Final report with immunohistochemical staining showed a high-grade MFS. After the procedure, there was clinical and radiological improvement, and the patient was followed up as an outpatient. Myxofibrosarcoma is a very rare and aggressive connective tissue neoplasm with variable presentations. Surgical resection is the preferred treatment. Prompt diagnosis and adequate management of these tumors are important to reduce their high local recurrence and distant metastasis rates. Therefore, it is important to be aware of its common and uncommon presentations.Copyright © 2021 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.

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