• Chest · Jan 2022

    Case Reports

    A 21-Year-Old Man With Dyspnea, Wheezing, and Cough.

    • Uddalak Majumdar, Umur Hatipoğlu, and James K Stoller.
    • Respiratory Institute, Cleveland Clinic, Cleveland, OH. Electronic address: majumdu@ccf.org.
    • Chest. 2022 Jan 1; 161 (1): e13-e17.

    Case PresentationA 21-year-old male college student presented for a second opinion with low alpha-1 antitrypsin (AAT) levels and complaints of episodic dyspnea with wheezing and cough. He was a never smoker with a medical history of frequent respiratory tract infections in early childhood and allergy to dander, dust mites, peanuts, and eggs. There was no travel history outside of the continental United States. His mother had asthma. His symptoms were not controlled on inhaled corticosteroids and bronchodilators. His AAT genotype was found to be PI∗SZ, and augmentation therapy (with pooled human-plasma derived AAT) was recommended locally.Copyright © 2021 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.

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