• J Headache Pain · Jan 2022

    Insulin sensitizes neural and vascular TRPV1 receptors in the trigeminovascular system.

    • Judit Rosta, Máté Tóth, Nadine Friedrich, Péter Sántha, Gábor Jancsó, and Mária Dux.
    • Department of Physiology, University of Szeged, Dóm tér 10, Szeged, H-6720, Hungary.
    • J Headache Pain. 2022 Jan 15; 23 (1): 7.

    BackgroundClinical observations suggest that hyperinsulinemia and insulin resistance can be associated with migraine headache. In the present study we examined the effect of insulin on transient receptor potential vanilloid 1 (TRPV1) receptor-dependent meningeal nociceptor functions in rats.MethodsThe effects of insulin on the TRPV1 receptor stimulation-induced release of calcitonin gene related peptide (CGRP) from trigeminal afferents and changes in meningeal blood flow were studied. Colocalization of the insulin receptor, the TRPV1 receptor and CGRP was also analyzed in trigeminal ganglion neurons.ResultsInsulin induced release of CGRP from meningeal afferents and consequent increases in dural blood flow through the activation of TRPV1 receptors of trigeminal afferents. Insulin sensitized both neural and vascular TRPV1 receptors making them more susceptible to the receptor agonist capsaicin. Immunohistochemistry revealed colocalization of the insulin receptor with the TRPV1 receptor and CGRP in a significant proportion of trigeminal ganglion neurons.ConclusionsInsulin may activate or sensitize meningeal nociceptors that may lead to enhanced headache susceptibility in persons with increased plasma insulin concentration.© 2022. The Author(s).

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