• Laura Lucaccioni, WongSze ChoongSCDevelopmental Endocrinology Research Group, School of Medicine, University of Glasgow, Dalnair Street, Glasgow, UK., Arlene Smyth, Helen Lyall, Anna Dominiczak, S Faisal Ahmed, and Avril Mason.
• Developmental Endocrinology Research Group, School of Medicine, University of Glasgow, Dalnair Street, Glasgow, UK.
• Br. Med. Bull. 2015 Mar 1; 113 (1): 45-58.

BackgroundTurner syndrome (TS) is associated with a spectrum of health problems across the age span, which requires particular attention during the transition period in these adolescents.Areas Of AgreementThe majority of girls with TS require oestrogen replacement from puberty onwards, which is important for adequate feminization, uterine development and maintenance of bone health. There is a lifetime increased risk from autoimmune conditions like hypothyroidism, coeliac disease, hearing loss and aortic dilatation with the potential to lead to aortic dissection. A systematic and holistic approach to provision of health care in TS is needed.Areas Of ControversySeveral unanswered questions remain, including the choice of hormone replacement therapy in the young person with TS and in adulthood; the optimal mode of cardiovascular assessment; the best management and assessment prior to and during pregnancy.Areas Timely For Developing ResearchThe optimal model of care and transition to adult services in TS requires attention. Further research is needed in relation to cardiovascular risk assessment, pregnancy management and hormone replacement therapy in TS.© The Author 2014. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

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