• Zeynel Abidin Tas and Ozgur Kulahci.
• Department of Pathology, University of Health Sciences, Adana City Education and Research Hospital, Adana, Turkey.
• J Coll Physicians Surg Pak. 2022 Feb 1; 32 (2): 166-170.

ObjectiveTo determine the effectiveness of Milan system for the evaluation of aspiration cytology to salivary gland lesions classification.Study DesignCross-sectional observational study.Place And Duration Of StudyDepartment of Pathology, Tertier Centre, University of Health Sciences, Adana City Education and Research Hospital, Adana, Turkey from January 2014 to December 2020.MethodologySalivary gland aspiration cytology of the last six years was recategorised, according to Milan classification. Risk of malignancy (ROM) and risk of neoplasm (RON) were determined among the subgroups in the cytological materials of 233 patients, who had undergone excisional biopsy.ResultsForty hundred and eighty salivary gland aspiration cytologies were available, in which 250 (52.1%) cases were males and 230 (47.1%) were females. The mean age was 52.36 ± 16.05 years. When aspiration cytology of 233 patients with resection were evaluated, according to Milan classification, ROM in non-diagnostic category was 9.5%, ROM in non-neoplastic category was 19.2%, and ROM in neoplasm-benign category was 8.2%. ROM were found 100% in the suspected malignancy and malignancy categories. There were no patients in the atypia category of undeterminate significance.ConclusionIn aspiration cytology of salivary gland lesions, Milan system provides useful information in classifying patients for clinical follow-up and treatment. However, it can be said that it is difficult to distinguish between the atypia of uncertain significance and neoplasm categories. Key Words: Salivary glands, Biopsy, Fine-needle, Milan classification.

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