• Med Klin · Aug 1997

    Case Reports

    [Hyperferritinemia in Still syndrome in the adult and reactive hemophagocytic syndrome].

    • R C Zollner, P Kern, H Steininger, J R Kalden, and B Manger.
    • Medizinische Abteilung, Klinikum Deggendorf.
    • Med Klin. 1997 Aug 15; 92 (8): 494-8.

    AbstractThis report describes the fatal outcome of a case of adult onset Still's disease in a 46-year old man. The diagnosis was made according to the 1992 criteria, proposed by Yamaguchi. Nine months after the initial disease manifestations a rapid deterioration with progressive hepatosplenomegaly developed. In parallel, pancytopenia and marked hyperferritinemia could be detected. Transjugular liver biopsy revealed the presence of a hemophagocytic syndrome. The course of the disease was refractory to any form of treatment and the patient died from disseminated intravascular coagulation, hepatic and pulmonary failure. Pathogenetic mechanisms and possible associations between Still's disease and reactive hemophagocytic syndrome are discussed.

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