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- F Berenbaum.
- Praticien Hospitalo, Universitaire, Service de Rhumatologie, Paris. francis.berenbaum@sat.ap-hop-paris.fr
- Presse Med. 1999 Jun 19; 28 (22): 1182-7.
AbstractA NEW CLASS OF NSAID: All non-steroidal antiinflammatory drugs (NSAID) inhibit cyclooxygenase (COX) and prostaglandin synthesis implicated in inflammatory processes and also participate in protecting the gastric mucosa. The discovery of two isoforms of COX, called COX-1 and COX-2 has led to further research into dissociating NSAID efficacy and intolerance. COX-1 AND COX-2: It appears that the antiinflammatory and antalgesic effects of NSAID is related to COX-2 inhibition while the undesirable effects on the gastric mucosa would be related to COX-1 inhibition. A COX-2 specific inhibitor would thus provide the same efficacy as classic NSAID but without the digestive disadvantages.
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