-
Review Comparative Study
[Objectives for antibiotic therapy in acute exacerbations of chronic bronchitis].
- J Gaillat.
- Service des maladies infectieuses, Centre hospitalier de la région Annecienne, Annecy.
- Presse Med. 2001 Oct 27; 30 (31 Pt 2): 17-22.
AbstractANTIBIOTIC EFFICACY: According to early studies, antibiotics have moderate efficacy in acute exacerbation of chronic bronchitis. The lack of efficacy is particularly clear for patent exacerbation with marked alteration of respiratory function. Recent studies have shown that newer compounds exhibit an efficacy similar (no proven superiority) to comparison compounds (75 to 95% favorable outcome with treatment). The recommendations of the IVth Consensus Conference on Anti-infectious Therapy thus propose first line antibiotic therapy for patients with a forced expiratory volume in 1 second (FEV1) between 80 and 35% and broader spectrum and new antibiotics in case of failure of the first line treatment for patients with severe obstruction or frequently recurrent exacerbation.
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