• Luciana Sepúlveda-Pezoa, Daniela Gómez-Pérez, Manuel S Ortiz, Belén Salinas-Rehbein, and Margarita Cancino.
• Laboratorio de Estrés y Salud, Facultad de Educación, Ciencias Sociales y Humanidades, Universidad de La Frontera, Temuco, Chile.
• Rev Med Chil. 2021 Aug 1; 149 (8): 1134-1140.

BackgroundSeveral risk factors are associated with cognitive impairment in older people, but little attention has been paid to cardiometabolic variables, as well as how cognitive reserve can mediate this association.AimTo determine the association of cardiometabolic risk factors with cognitive functioning and whether the cognitive reserve mediates this association.Material And MethodsA cross-sectional study with 300 participants with a median age of 56 years (53% male) was conducted. Participants had a cognitive functioning assessment. Fasting glucose, HDL-cholesterol, and blood pressure were measured.ResultsA Structural Equation Modeling, revealed a direct effect of cardiometabolic latent risk factors on both a cognitive functioning (β = -.204; p = .056), and cognitive reserve factors (β = -.236, p = .04). Cognitive reserve was directly associated with cognitive functioning (β = .327, p = .01), but did not mediate the association between the cardiometabolic risk factors and cognitive functioning (β = .077, p = .07). The overall goodness of fitness was excellent χ2 (50) = 58.357, p = .195, comparative fit index = .980, Tucker-Lewis Index = .974, root mean square error of approximation = .023 and Standardized Root Mean Square Residual = .041.ConclusionsA direct effect of cardiometabolic risk factors on cognitive functioning was observed.

12 keywords...

hide…