• Clinics · Oct 2006

    Comparative Study

    Diacerhein versus glucosamine in a rat model of osteoarthritis.

    • Márcia Uchôa de Rezende, Henrique Melo de Campos Gurgel, Paulo Roberto Vilaça Junior, Rogério Kawassaki Kuroba, Alex Silva Santiago Lopes, Renée Zon Phillipi, and Arnaldo José Hernandez.
    • Biomechanics Laboratory, Institute of Orthopedics and Traumatology, Hospital das Clínicas, São Paulo University Medical School, São Paulo, SP, Brazil. murezende@uol.com.br
    • Clinics (Sao Paulo). 2006 Oct 1; 61 (5): 461-6.

    PurposeThe purpose of this study was to compare the chondroprotective effect of diacerein and glucosamine regarding degenerative changes and articular stiffness in an experimental model of arthritis.MethodsTwenty rats underwent medial meniscectomy on the right knee. Ten animals were given diacerhein, and 10 were given glucosamine, from day 1 to the third month postoperatively, when all of them were killed. Histological and functional analysis of the knees were performed (measurement of maximum extension).ResultsAll operated knees showed more limited extension values and more degenerative changes as compared to nonoperated contralateral sides. A comparison of the two drugs showed that the degree of articular stiffness was significantly lower with diacerein, although degenerative changes were similar.Conclusions1) Prophylactic use of diacerein leads to lower degree of articular stiffness when compared to glucosamine; 2) The prophylactic chondroprotective effects of diacerein and glucosamine are histologically similar.

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