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- Christian Jamin, Christophe Poncelet, and Patrick Madelenat.
- Service de gynécologie-obstétrique CHU Bichat, 46, rue Henri Huchard 75018 Paris.
- Presse Med. 2002 Sep 7; 31 (28): 1314-22.
AbstractINDIRECT MECHANISM OF ACTION: Tibolone (OD 14) is the precursor of its active principles that are its metabolites: 3 alpha and 3 beta hydroxylated derivatives. In vivo, the latter behave like estrogens. Certain tissues (liver, endometrium) may metabolize the 3 beta ol derivative into the delta 4 isomer with progestagenic and androgenic activity. The metabolism of the product in other tissues such as the breast and brain is unknown.
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