• Dominic O Co and Jennifer M Kwon.
• Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, University of Wisconsin - Madison, Clinical Science Center (CSC) H6/572, 600 Highland Avenue, Madison, WI 53792, USA. Electronic address: doco@wisc.edu.
• Crit Care Clin. 2022 Apr 1; 38 (2): 393-412.

AbstractAutoimmune encephalitis is characterized by subacute onset of the altered mental status that can rapidly progress to autonomic instability and refractory seizures requiring intensive care. It is mediated by autoantibodies that bind to synaptic surface proteins and alter their function. In contrast to many autoimmune CNS diseases, there is often little detectable inflammatory damage to the brain making it difficult to diagnose. Early engagement of a multidisciplinary team is essential to obtaining a complete diagnostic workup and instituting definitive therapy as early as possible to optimize outcomes. Diagnosis, treatment, and monitoring for this devastating condition continue to evolve. Pathogenesis, diagnosis and both current and emerging therapies are reviewed.Copyright © 2021 Elsevier Inc. All rights reserved.

16 keywords...

hide…