• J. Korean Med. Sci. · Jan 2019

    The Association of Adiponectin and Visceral Fat with Insulin Resistance and β-Cell Dysfunction.

    • Hyun Uk Moon, Kyoung Hwa Ha, Seung Jin Han, Hae Jin Kim, and Dae Jung Kim.
    • Department of Endocrinology and Metabolism, Ajou University School of Medicine, Suwon, Korea.
    • J. Korean Med. Sci. 2019 Jan 7; 34 (1): e7.

    BackgroundObesity is a risk factor for metabolic abnormalities. We investigated the relationship of adiponectin levels and visceral adiposity with insulin resistance and β-cell dysfunction.MethodsThis cross-sectional study enrolled 1,347 participants (501 men and 846 women aged 30-64 years) at the Cardiovascular and Metabolic Diseases Etiology Research Center. Serum adiponectin levels and visceral fat were measured using enzyme-linked immunosorbent assay kits and dual-energy X-ray absorptiometry, respectively. Insulin resistance was evaluated using the homeostatic model assessment of insulin resistance (HOMA-IR) and Matsuda insulin sensitivity index. β-cell dysfunction was evaluated using the homeostatic model assessment of β-cell function (HOMA-β), insulinogenic index, and disposition index.ResultsRegarding insulin resistance, compared with individuals with the highest adiponectin levels and visceral fat mass < 75th percentile, the fully adjusted odds ratios (ORs) for HOMA-IR ≥ 2.5 and Matsuda index < 25th percentile were 13.79 (95% confidence interval, 7.65-24.83) and 8.34 (4.66-14.93), respectively, for individuals with the lowest adiponectin levels and visceral fat ≥ 75th percentile. Regarding β-cell dysfunction, the corresponding ORs for HOMA-β < 25th percentile, insulinogenic index < 25th percentile, and disposition index < 25th percentile were 1.20 (0.71-2.02), 1.01 (0.61-1.66), and 1.87 (1.15-3.04), respectively.ConclusionLow adiponectin levels and high visceral adiposity might affect insulin resistance and β-cell dysfunction.

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