• Isr Med Assoc J · Mar 2016

    Review

    Vitamin D and Systemic Lupus Erythematosus: Myth or Reality?

    • Abdulla Watad, Shana G Neumann, Alessandra Soriano, Howard Amital, and Yehuda Shoenfeld.
    • Isr Med Assoc J. 2016 Mar 1; 18 (3-4): 177-82.

    AbstractThere is growing interest in the contribution of vitamin D deficiency to autoimmunity. Several studies have shown an association between low levels of vitamin D and autoimmune disorders, including multiple sclerosis, rheumatoid arthritis, type 1 diabetes, autoimmune thyroid diseases, celiac disease, and systemic lupus erythematosus (SLE). Vitamin D receptor ligands can mediate immunosuppressive effects. It has been suggested that low levels of this hormone contribute to the immune activation in lupus and other autoimmune diseases. This review updates and summarizes the literature on the association between vitamin D and SLE, and discusses the various correlations between vitamin D and SLE activity, clinical expressions, serology, and gene polymorphisms of vitamin D receptors.

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