• Huynh Trung Trieu, Lam Phung Khanh, Damien Keng Yen Ming, Chanh Ho Quang, Tu Qui Phan, Vinh Chau Nguyen Van, Ertan Deniz, Jane Mulligan, Bridget Ann Wills, Steven Moulton, and Sophie Yacoub.
• Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam. trieuht@oucru.org.
• Bmc Med. 2022 Apr 7; 20 (1): 109.

BackgroundDengue shock syndrome (DSS) is one of the major clinical phenotypes of severe dengue. It is defined by significant plasma leak, leading to intravascular volume depletion and eventually cardiovascular collapse. The compensatory reserve Index (CRI) is a new physiological parameter, derived from feature analysis of the pulse arterial waveform that tracks real-time changes in central volume. We investigated the utility of CRI to predict recurrent shock in severe dengue patients admitted to the ICU.MethodsWe performed a prospective observational study in the pediatric and adult intensive care units at the Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam. Patients were monitored with hourly clinical parameters and vital signs, in addition to continuous recording of the arterial waveform using pulse oximetry. The waveform data was wirelessly transmitted to a laptop where it was synchronized with the patient's clinical data.ResultsOne hundred three patients with suspected severe dengue were recruited to this study. Sixty-three patients had the minimum required dataset for analysis. Median age was 11 years (IQR 8-14 years). CRI had a negative correlation with heart rate and moderate negative association with blood pressure. CRI was found to predict recurrent shock within 12 h of being measured (OR 2.24, 95% CI 1.54-3.26), P < 0.001). The median duration from CRI measurement to the first recurrent shock was 5.4 h (IQR 2.9-6.8). A CRI cutoff of 0.4 provided the best combination of sensitivity and specificity for predicting recurrent shock (0.66 [95% CI 0.47-0.85] and 0.86 [95% CI 0.80-0.92] respectively).ConclusionCRI is a useful non-invasive method for monitoring intravascular volume status in patients with severe dengue.© 2022. The Author(s).

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